Can you run from the shoutgun sets?

I have heard that you can get good yards from plays from the shotgun sets. Most time people who i play against once they see me go to shoutgun they either go to quarters and blitz or they play the pass. So i ask the question what plays would be good to used to run out of the shotgun set. The playbooks that i used are the falcons the sandiego chargers the redskins and saints and the 49niners and the pass balance playbook. Thanks for your help ALC

Eww shotgun i never do shotgun unless my opponent is weak. But yeah you can get some decent runs out of shotgun but you have to read where pressure is coming from and find the hole

i only can do that if they are looking for the pass, so i'll do a hb draw